Because CHH also presents with defective immunity caused by T-cell deficiency (42) and together with our findings that viperin and CXCL10 regulate chondrogenic differentiation, is thus tempting to speculate that interferon-related signaling through viperin and via CXCL10 is an important aspect of the molecular mechanism leading to growth plate and T-cell defects observed in CHH. The gene discussed is CXCL10; the disease is congenital T-cell immunodeficiency.