In a recent study published in Molecular Cell, entitled “LncRNA CamK-A regulates Ca(2+)-signaling-mediated tumor microenvironment remodeling” Sang et al. [6], described a novel lncRNA named lncRNA for calcium-dependent kinase activation (CamK-A), which is shown to mediate the cross-talk between calcium signaling and the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to promote the Warburg effect, microenvironment remodeling, and tumor development (Fig. 1). Here, CAMK2A is linked to neoplasm.