Overall, our findings suggest that miR-205 exerts its radiosensitizing effect mainly by impairing DNA repair pathways through the inhibition of ZEB1 and the suppression of PKCε-EGFR-DNA-PK axis, respectively, ultimately resulting in a decrease removal of radiation-induced DNA lesions and consequent enhancement of PCa cell susceptibility to radiation. Here, PRKDC is linked to posterior cortical atrophy.