Target choice was based on previous findings indicating that PKCε plays a central role in radiation response of A549 lung carcinoma cells by inducing nuclear translocation of EGFR and activation of DNA-PK [23], together with the evidence that miR-205 increased radiation response of breast cancer models through ZEB1 suppression and consequent inhibition of homologous recombination (HR) repair of DNA-DSBs [4]. This evidence concerns the gene PRKDC and breast cancer.