While miR-205-induced inhibition of ZEB1 and of the ubiquitin-conjugating enzyme Ubc13, and the consequent decrease in the ability to repair DNA damage by the homologous recombination (HR) pathway, has been exhaustively documented as a main responsible for the miRNA radiosensitizing effect in breast cancer cells [4], the role of PKCε in miR-205-mediated increased radiation response of tumour cells has never been investigated. The gene discussed is UBE2N; the disease is breast cancer.