Besides the significant role of CD3+, CD8+ and CD20+ lymphocytes at both intratumoral regions in pCR, our results revealed that the infiltration of the TC with total TILs and CD3+ T cells was also significantly associated with NACT response and the pathological regression score [48] and was also described for entire tumor analyses in other neoadjuvant BC TIL studies [28, 29, 54, 63, 68]. Here, CD8A is linked to neoplasm.