Tumor size pre-NACT (cT-stage) was inversely correlated with the density of total TILs, CD3+ T cells and CD4+ T lymphocytes in the TC; they were highly present at early stages (cT1) and then decreased along with tumor progression (p = 0.004 for total TILs and CD3+ and p = 0.011 for CD4+ T cells). This evidence concerns the gene CD4 and neoplasm.