It has been reported that CFTR deficiency causes defective autophagic flux in both human airway epithelial cells and nasal biopsies from CF patients, leading to the formation of aggresome through the production of ROS, upregulation of tissue transglutaminase (TG2), sequestration of the class III PI3K complex and subsequent accumulation of p62 [126,127]. The gene discussed is TGM2; the disease is cystic fibrosis.