CD8A and infection: To avoid such infection-enhancing vaccines, the current study took an approach to select epitopes (i) devoid of enhancing epitope from the target proteins, (ii) select epitopes from the target proteins that are known to induce CD8+ CTL responses, (iii) select epitopes for enhanced polyfunctional CD8+ T-cell responses, and (iv) screen for epitope that produces least amount of pro-inflammatory cytokines [4,48].