Upon BCG infection but not H37Rv infection with IFN-γ treatment, 15 of them (DDX60, IFI27, IFI6, IFIT1, IFITM1, IRF7, IRF9, ISG15, LY6E, MDA5, MX1, NAMPT, OASL, PML, and STAT1) exhibited a synergistic increase in TB patients (Figure 4). This evidence concerns the gene ISG15 and infection.