Surprisingly, 10 out of 28 ISGs (DDX60, IFIT1, IFITM1, IRF7, ISG15, LY6E, interferon-induced GTP-binding protein Mx1 (MX1), protein kinase R (PKR), promyelocytic leukemia (PML), and RTP4) induced by BCG infection and two of them (IFITM1 and IRF7) induced by H37Rv presented a further enhancement in hMDMs isolated from TB patients compared with healthy people. The gene discussed is ISG15; the disease is tuberculosis.