TREX1 and infection: We further detected 28 of the ISG expression levels upon H37Rv infection at multiplicities of infection 2 (MOI = 2) for 6, 24, and 48 h and approximately 90% (25 out of 28) of the ISGs (except for LY6E, RTP4, and TREX1) were significantly increased in hMDMs (Figure 1B).