More recently, Ahn et al. showed that co-targeting IL-10 receptor and TGF-β in DCs by siRNAs enhanced the immunogenic function of DCs, resulting in a significant anti-tumour effect against highly immune resistant tumour cells that secrete more IL-10 and TGF-β than the parental tumour cells [84]. The gene discussed is TGFB1; the disease is neoplasm.