Our quantitative RT-PCR analysis showed no statistically significant differences in NFKB1 mRNA levels in IVD tissue collected from DDD patients and the PM controls (Figure 1a), whereas a downregulation (p = 0.0001) of RELA mRNA levels was observed for DDD patients compared to the PM controls (Figure 1b). The gene discussed is NFKB1; the disease is Dowling-Degos disease 1.