TRPV1 and Dowling-Degos disease 1: However, nuclear NF-κB1–DNA binding correlated positively with SP (r = 0.462; p = 0.03; n = 22) and with TRPV1 (r = 0.718; p = 0.0001; n = 24) protein levels in IVD tissues extracted from DDD patients (Figure 5d,e).