A positive correlation was observed between NFKB1 and TRPV1 gene expression (r = 0.823; p = 0.0001; n = 35) and between RELA and TRPV1 mRNA (r = 0.624; p = 0.0001; n = 35) levels in IVD tissues collected from DDD patients (Figure 5a,b). This evidence concerns the gene RELA and Dowling-Degos disease 1.