PRKN and Parkinson disease: Although it represents less than 10% of all PD cases, at least 17 autosomal dominant and autosomal recessive gene mutations, namely, α-SYN (SNCA), PARKIN (PRKN), ubiquitin C-terminal hydrolase L1 (UCHL-1), PTEN-induced putative kinase 1 (PINK1), protein deglycase (DJ-1, PARK7), and leucine-rich repeat kinase 2 (LRRK2, PARK8) genes, among others have been identified [27].