Following on this work we have identified the presence of important neuroregulatory molecules in the secretome of MSCs, including BDNF, IGF-1, VEGF, Pigment epithelium-derived factor (PEDF), DJ-1, and Cystatin-C (Cys-C), that are being described as potential therapeutic mediators against PD [62,65], as well as matrix metalloproteinases (MMPs), namely MMP 2, known for being able to degrade alpha synuclein aggregates [65,66], and have correlated their presence with the impact observed in our in vitro and in vivo models. The gene discussed is SNCA; the disease is Parkinson disease.