Shiozawa et al., have also elegantly illustrated the cytotoxic effect of redox-silent analogue of tocotrienol in inhibiting survival of PC3 cells (androgen-independent prostate cancer (PCa) cell line) under hypoxia, through inhibition of Fyn/HIF-1α signaling cascade, which may lead to the establishment of a new effective therapy for PCa [87]. The gene discussed is HIF1A; the disease is posterior cortical atrophy.