VEGFA and colorectal cancer: In human colorectal cancer cell lines (HCT-116, HT-29 and Caco-2), γ-T3 administration in conjunction with capecitabine was reported to attenuate proteins associated with survival (Survivin, cIAP-1, and cIAP-2), proliferation (cyclin D1 and c-myc), and metastasis (MMP-9, VEGF, ICAM-1, and CXCR4) by down-regulating NF-κB/p65 pathway [88].