NOTCH1 and neoplasm: Rajasinghe and colleagues in 2018, documented that δ-T3 can alleviate tumor invasion and metastasis in A549 and H1299 cells by repression of protease activity of MMP-9/urokinase-type plasminogen activator (uPA) through down-regulation of Notch-1 and NF-κB pathways and up-regulation of miR-451 in NSCLC (Figure 4) [95].