In addition, overexpression of CDC42SE1 reduced colony numbers and size of A431SE1 cells compared to A431SE1-H38A and A431Ctrl cells in clonogenic assay, suggesting that CDC42SE1 inhibits tumor initiation and cell survival [56] in A431 cells compared to A431Ctrl and A431SE1-H38A cells. Here, CDC42SE1 is linked to neoplasm.