The findings from this study, together with data from EEG analyses conducted in Fmr1 KO mice [82], and from clinical EEG studies in subjects with FXS [83], are important because (a) they provide new insight into cortical defects in the disorder, and (b) indicate that EEG may be a very useful tool as an endpoint measurement in clinical trials for FXS. Here, FMR1 is linked to fragile X syndrome.