Third, hyperglycemia activates the thioredoxin-interacting protein (TXNIP)-mediated NLRP3 inflammasome in adipose tissues and microvascular endothelial cells, which are relevant to type 2 diabetes and myocardial ischemic/reperfusion injury, respectively [235,236,237]. Here, NLRP3 is linked to type 2 diabetes mellitus.