It is well established that chronic inflammation, induced by proinflammatory cytokines including IL-1β processed by the activated NLRP3 inflammasome, is associated with obesity and resultant metabolic syndromes, such as type 2 diabetes mellitus, atherosclerosis, and cardiac vascular diseases, which are leading causes of death [222,223,224,225,226,227,228]. This evidence concerns the gene NLRP3 and type 2 diabetes mellitus.