IL18 and cancer: Table 1 shows a summary of representative meta-analyses and/or systematic reviews of individual diseases. Therefore, IL18 promoter variants are associated with diverse diseases such as chronic viral infection, chronic diseases, and cancer. Therefore, these promoter variants might influence pro-IL-18 production although they might not influence the release of biologically active IL-18. Therefore, how IL18 promoter variants are associated with the risk of individual diseases remains to be elucidated.