The production of different substances from adipose tissue, such as tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein–1 (MCP-1), interleukin 6 (IL-6), and C-reactive protein (CRP), which are known to influence insulin resistance and the secretion of anabolic hormones, such as insulin and growth hormone (GH), could induce sarcopenic obesity [1,25,26]. The gene discussed is TNF; the disease is Insulin resistance.