We have found that in stroke neuroprotection studies, inhibition of DLDH by 5-methoxyindole-2-carboxylic acid (MICA) was able to activate the Nrf2 signaling pathway that leads to NAD(P)H quinone dehydrogenase 1 (NQO1) upregulation [44,64]. This evidence concerns the gene NQO1 and Stroke.