Although the other identified MiRs do not seem to be induced by hypoxia, they can directly alter HIF1α expression and reduce HIF-dependent angiogenesis and tumour survival in multiple cancer cell types including lung, breast and gastric carcinoma cell lines [63,64,65,66,67,68,69,70,71], representing an isoform-specific control of HIF isoforms in malignant cells. The gene discussed is HIF1A; the disease is cancer.