Recently, Pirola et al. [5] performed an OMIC s integrative analysis, selecting a list of genes associated with NAFLD and metabolites known to be altered in NAFLD and NASH and observed interesting results on some pathways involved in NAFLD pathophysiology: the ATP binding cassette family (ABCC) and solute carriers transporters (SLC). This evidence concerns the gene CCL21 and metabolic dysfunction-associated steatotic liver disease.