On the contrary, Stat3 downregulation in immortalized, non-transformed lung epithelial cells or in the NSCLC lines displaying extensive GJIC actually suppressed junctional permeability, in a manner similar to the T51B/T51B-Src system (Figure 3A(d–f),B(d–f)), pointing to a positive role of Stat3 upon GJIC. The gene discussed is SRC; the disease is non-small cell lung carcinoma.