NRPs are multifunctional non-tyrosine kinase receptors for VEGF, TGFβ, and semaphorins, which are, in addition to their role in axonal guidance, associated with tumor proliferation, angiogenesis, and survival by triggering growth-promoting signal transduction pathways (Figure 3) [90,158,159]. Here, TGFB1 is linked to neoplasm.