Distinguishing between the two NRP isoforms, the small molecule inhibitor EG01377 selectively binds to the arginine-binding pocket of NRP1 without binding to NRP2, and it functionally inhibits VEGF-A-induced angiogenesis, cell migration, melanoma cell invasiveness, and Treg cell activation with good stability in vivo [373]. The gene discussed is NRP2; the disease is melanoma.