This explains the regulatory interaction between integrins and NRPs, for example in the upregulation of the collagen-binding integrin α2β1 upon stimulation with the NRP1-agonist SEMA3A in breast cancer cells [154], the enhanced expression of αvβ3 integrin upon blockage of NRP1 [155], and reciprocally the inhibitory sequestering of NRP1 from the NRP1-VEGFR2 signaling complex by αvβ3 integrin in ECs [156]. Here, NRP1 is linked to breast carcinoma.