NRP2 and gastric cancer: NRP2 occurs in gastric cancer, and its silencing in a gastric cancer cell line leads to a decreased expression of the metastasis mediator S100A4, mediated via Wnt/β-catenin signaling and accompanied by downregulation of anti-apoptotic B-cell lymphoma 2 (Bcl-2) and concomitant upregulation of pro-apototic caspases -3 and -7 [254].