In contrast to previous work, which mainly examined virally induced HCC, our analysis was performed on a Caucasian, non-viral-dominant cohort of PLC patients and shows insight into the clinical relevance of the cellular localization of YAP and TAZ in HCC K19−, HCC K19+, cHCC-CCA, and CCA cases. Here, HSPG2 is linked to cholangiocarcinoma.