It has been shown that, in cases of the aggressive non-Hodgkin lymphoma of T/null cell called anaplastic lymphoma kinase-positive/anaplastic large cell lymphoma (ALK+-ALCL), the tyrosine kinase enzymatic activity of the Hsp90-binding oncoprotein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) induces the expression of both immunophilins, FKBP52 and Cyp40, but not that of FKBP51 [162]. The gene discussed is NPM1; the disease is anaplastic large cell lymphoma.