NF-κB (Nuclear Factor Κ-light-chain-enhancer of activated B cells) is indeed a relatively large family of transcription factors that regulate the expression of genes associated to pleiotropic processes such as the immune response, inflammatory diseases, cell development, cell growth, cancer progression, neuronal synaptic plasticity, memory, cell differentiation, etc. [114]. The gene discussed is NFKB1; the disease is cancer.