Vascular and lymphatic endothelial cells were also significantly more frequently Cx43 positive in melanomas (38/59, 64%) than in nevi (7/50, 14%) (p < 0.001), and this showed a progressive tendency from common nevi (1/9, 11%), through dysplastic nevi (6/41, 15%), thin melanomas (8/20, 40%), thick melanomas (15/23, 65%) to metastases (15/16, 94%), with a significant increase from dysplastic nevi to thin melanomas (p = 0.049) (Figure 5B). This evidence concerns the gene GJA1 and dysplastic nevus.