Increased Cx30 expression was observed in the epidermal microenvironment of melanomas [15,16], adjacent to healthy/normal epidermal keratinocytes expressing a wide range of Cxs (Cx30.3, Cx31, Cx31.1, Cx37 and Cx45 Cx30, Cx26, Cx43) [23]. This evidence concerns the gene GJB2 and melanoma.