Tumor adjacent epidermis also showed significantly higher Cx26 expression in melanomas (27/45; 60%) compared to nevi (8/63;13%) (p < 0.001), and this difference was also significant between thin (6/22, 27%) and thick (21/23, 91%) melanomas (p < 0.001) (Figure 5C,D). This evidence concerns the gene GJB2 and neoplasm.