GJA1 and melanoma: In datasets using GSE3189 arrays, melanomas showed downregulated GJA1 (Cx43; LogFC = −4.1; p < 0.001), GJB3 (Cx31; LogFC = −3.4; p < 0.001), GJB5 (Cx31.1; LogFC = −3.3; p < 0.001) and upregulated GJB1 (Cx32; LogFC = +1.5; p < 0.001) gene expression compared to nevi [26].