In GSE8401 arrays, metastatic melanomas from xenograft models showed downregulated GJA1 (Cx43; LogFC = −2.8; p < 0.001), GJB3 (Cx31; LogFC = −1.8; p < 0.001) and GJB5 (Cx31.1; LogFC = −1.1; p < 0.001) gene expression compared to primary melanomas [28]. This evidence concerns the gene GJB5 and melanoma.