Particularly, B-CPAP cells, harboring a genetic profile reflecting the aggressiveness of primary tumor from which derived (BRAF, TP53, and hTERT mutations), displayed the most perturbed metabolic phenotype, as demonstrated by altered levels of energetic metabolites (e.g. increase of F6P, DHAP, GAP, 3PG, PEP, and decrease of lactic acid). This evidence concerns the gene BRAF and neoplasm.