TARDBP and amyotrophic lateral sclerosis: Nishimoto et al. [116] were able to show a direct interaction of NEAT1 with two RNA-binding proteins, both of which are mutated in ALS patients, i.e., TAR DNA-binding protein 43 (TDP-43) [117] and fused in sarcoma/translocated in liposarcoma (FUS/TLS) [118].