NEAT1 is upregulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model together with PINK1 (a known contributor to PD [120]) which was stabilized by NEAT1. Since a knockdown of NEAT1 leads to reduced MPTP-initiated autophagy in vivo resulting in a decreased neuronal injury, authors claim that there is a contribution of NEAT1 in PD. This evidence concerns the gene NEAT1 and Parkinson disease.