To explore the underlying mechanism mediating this effect we initially investigated cell growth in COLO320DM (APC mutated/KRAS WT) and HCT-15 (APC mutated/KRAS mutated) colorectal cancer cells under the influence of 1 μM G007-LK (TNKS inhibitor; TNKSi) and/or 1 μM GDC-0973 (MEK inhibitor; MEKi). Here, APC is linked to colorectal cancer.