MAP2K7 and osteoarthritis: On the other hand, MEK inhibition induced more significant transcriptional changes at the selected inhibitor dose which the IPA software (cutoff at lfc > ±2, padj < 0.01 [data input], z-score > ±0.4 [analysis output]) associated with reduced “ERK/MAPK signaling”, induced “PKA signaling” and induced “osteoarthritis pathway” (Figure S7B and Table S7).