In HCT-15 cells, reduced transcription of cell cycle mediating genes (CCND1, PCNA, CDK2, CDKN1B; Figure S15D,H,I), and reduced transcription of anti-apoptotic genes (BMI1, BIRC5 and BCL2; Figure S15D,J), support a cancer suppressive and favorable FOXO3/FOXM1 ratio [28] upon combined TNKSi/MEKi treatment. Here, FOXO3 is linked to cancer.