With a mild cutoff at log fold change (lfc) > ±0.5, padj < 0.1 [data input], z-score > ±2 (analysis output), the IPA software associated TNKSi induced DEG’s with enhanced “cholesterol biosynthesis”, enhanced “ErbB signaling”, enhanced “glioma invasiveness signaling” and enhanced “NFR2-mediated oxidative stress response” (Figure S7A and Tables S5 and S6). Here, EGFR is linked to central nervous system cancer.