This indicates that although the incidence of MTB disease in HIV-infected patients decreased significantly across the study periods, the majority of MTB events occurred when patients were severely immunocompromised (78.2% cases at CD4+ cell count < 200 cells/L), which could contribute to an increased rate of extrapulmonary TB and perhaps delay MTB disease diagnosis in patients with HIV [59,60]. The gene discussed is CD4; the disease is tuberculosis.