ATG5 and cancer: Boya et al. 2005 [70] demonstrated on this condition the blunting of autophagy by impeding their early stage with 3MA treatment, followed by the inhibition of auto phagolysosome formation by hydroxychloroquine (HCQ) or bafilomycin A1 or the silencing of several genes such as Atg5, Beclin1, Atg10, or Atg12 by RNA interference, which has been shown to facilitate the death of starved cancer cells [70].