COL1A2 and osteoporosis: In turn, Majchrzycki et al (2017)17 found that the COL1A2 gene polymorphism may be a genetic risk factor related to the development of osteoporosis; and, lastly, Meng et al (2017)16 observed in a meta-analysis that rs42524 in the COL1A2 gene was associated with a significant increase in the risk of intracranial aneurysms in Japanese patients (allelic model: OR = 1.94; 95% CI: 1.03–3.64; p = 0.04).