Mutations that affect the COL1A2 gene reduce the biosynthesis of type I collagen and, consequently, could be involved in osteogenesis imperfecta.15 According to the literature, a polymorphism of the COL1A2 is associated with vascular disease and osteoporotic fractures.16, 17, 18 A recent meta-analysis suggests that COL1A2 rs42524 is a significant risk factor for intracranial aneurysm susceptibility, with an especially strong effect in Asian people.19 However, in our review, it was not possible to find studies evaluating the relationship of this polymorphism with POP. This evidence concerns the gene COL1A2 and osteogenesis imperfecta.