VEGFA and Hypertension: Systemic side effects have been reported after intravitreal injections of bevacizumab in humans, such as systemic hypertension, cerebrovascular accidents, and facial skin redness.22, 23 A decrease of plasma VEGF values after intravitreal bevacizumab injections has been described.24 However, there is no knowledge about effects on serum VEGF values and general safety after topically applied bevacizumab in dogs.