As shown in Fig 1, LP-80 exhibited the most potent activities in inhibiting HIV-1HXB2 Env-mediated cell-cell fusion, HIV-1NL4-3 pseudovirus-mediated single-cycle cell entry, and replication-competent HIV-1JRCSF-mediated infection, with mean 50% inhibitory concentrations (IC50s) of 12.61, 1.62, and 2.45 pM, respectively. This evidence concerns the gene ERVW-1 and infection.