The IAPa Debio 1143 (also called AT-406 or SM-406), which is used in the present study and which antagonizes cIAP1, cIAP2, and XIAP [50], is currently tested in various clinical trials for its anti-cancer efficacy in combination with chemo/radio-therapy, or immune checkpoint blockade in patients with advanced solid malignancies (NCT02022098, NCT03270176). This evidence concerns the gene BIRC3 and cancer.