AR and Familial prostate cancer: In castration-resistant prostate cancer cells, the reprogramming of the binding of lysine-specific demethylase 1A (LSD1), which is a histone-modifying enzyme responsible for demethylation of histone H3 lysine 4 (H3K4), results in an increase of AR binding at the CENPE promoter and subsequently enhanced CENPE transcription [12].