It was previously reported that in bronchial tissues of patients with asthma periostin colocalizes with other ECM proteins such as COLLI, COLLIII, COLLV, FN, and tenascin-C [41], whereas COLLs cross-linking is significantly reduced in periostin-deficient mouse skin, suggesting a role of this ECM-associated matricellular protein in the appropriate COLLs fibrillogenesis [42]. Here, POSTN is linked to asthma.