KLK3 and neuroblastoma: However, small children and pregnant women are often systematically screened for more than 100 conditions that are even rarer than neuroblastoma.34 Moreover, the theory underlying screening of asymptomatic individuals is the same for any disease, irrespective of age, sex, location, and incidence.35 Last, the poor benefit-to-harm balance of screening for prostate cancer using the serum prostate specific antigen test has also been compared with that of screening for neuroblastoma.36