Previous work has shown that Alu-mediated recombination is responsible for homozygous deletions in the STK11/LKB1 locus of HeLa cells to generate aberrant LKB1 fusion transcripts (54), for MLL/KMT2A duplications in normal and AML hematopoietic cells (55), and for nonallelic homologous recombination deletions in the FANCA, B, C and D2 genes (5,56) in FA patient cells. Here, KMT2A is linked to acute myeloid leukemia.