This was further validated using electron microscopy, whereby 6-month C3KI.C5KO mice showed healthy glomeruli and no evidence of electron-dense deposits (Figure 8G), similar to aged-matched WT (Figure 8H) and in contrast to 6-month FH-KO animals, which showed pathological features of C3 glomerulopathy (Supplemental Figure 10J). Here, FH is linked to complement 3 glomerulopathy.