Nevertheless, levels of C3 in the C3KI.C5KO mice were significantly (P < 0.0001) higher than the levels reported in the FH-KO mice (current model of C3 glomerulopathy), where all the fluid-phase C3 had been consumed (Figure 2C; ref. 41). The gene discussed is FH; the disease is complement 3 glomerulopathy.