ERBB2 and hepatocellular carcinoma: The ERBB2 oncogene hypothesis, that overexpression of HER2 correlates etiologically with tumorgenesis,33 has been challenged by some studies claiming that HER2 was rarely overexpressed in HCC or might not play an essential role in the process of HCC.11, 12, 13, 14, 15 Our study supported the hypothesis with the evidences of HER2 expression and its function in HCC.