As to the function of HER2 in HCC tumorgenesis, our analysis suggested that regulation of HER2 may affect the epithelial‐to‐mesenchymal transforming more than tumor cell survival, and the later has been highlighted in the breast cancer and other tumor types.9, 10 Intravenous Trastuzumab infusion decreased in vivo tumor growth significantly, which may partly be related with Trastuzumab, a humanized monoclonal antibody, which may invoke systematic unspecific response and affect the inoculated tumor growth. This evidence concerns the gene ERBB2 and neoplasm.