Despite that HER2 might be upregulated in the transformed state of hepatocyte, HER2 is found not expressed in the normal liver and adult primary hepatocytes, or not appreciably induced in the regenerating liver after partial hepatectomy.20 Enlightening the expression of HER2 and its further mechanism in HCC could be a new target as a treatment option for HCC as well as tumor recurrence after surgery. This evidence concerns the gene ERBB2 and hepatocellular carcinoma.