ERBB2 and neoplasm: This result was supported by a recent bioinformatics analysis on differentially expressed genes between liver cancer samples and normal samples, which identified ERBB2 as one of top 10 key genes related with HCC initiation and progression28 In addition, the status that HER2 expression in the tumor correlates negatively with the tumor stage was supported with both the gene analysis of GSE89377 and TCGA HCC cohort, and the immunostaining analysis of the patient samples and clinical data through the correlation analysis of HER2 expression pattern and the tumor stage.