IL1B and familial Mediterranean fever: The diagnosis of FMF is based on the presence of clinical symptoms and can be supported by genetic testing, but the absence of mutation does not exclude the disease.3 The gene responsible for FMF, designated MEFV, encodes a protein named as pyrin (alternatively marenostrin) which is primarily expressed in polymorphonuclear cells, cytokine‐activated monocytes, and synovial fibroblasts.4, 5 Pyrin has an important role in the inflammatory response by regulating caspase‐1 activation and processing mature IL‐1β.6