STK39 and hypertensive disorder: 2011; Shekarabi et al. 2017; Murthy et al. 2017). It has been previously found that knock‐in mice that express a SPAK form that is unable to be activated by WNK kinases are significantly salt‐wasting and hypotensive (Rafiqi et al. 2010). The inhibition of the SPAK‐dependent signaling pathway has been proposed as an exciting prospect in therapy of hypertension (Cohen and Alessi 2013; Alessi et al. 2014; Yamada et al. 2016; AlAmri et al. 2017).