GPER1 and endometrial cancer: For example, activation of GPR30 by G1 shows an anti‐apoptotic effect through PI3K following spinal cord injury in adult female mice72, 73; moreover, inactivation of GPR30 by G15 inhibits E2‐induced activation of PI3K in Boar Sertoli cells74 and AKT phosphorylation in endometrial cancer cells.75 Furthermore, GPR30 has been shown to regulate neurite genesis in developing hippocampal neurons via PI3K activation.51 However, it is unclear whether PI3K mediates GPR30 regulation of actin cytoskeleton polymerization and synaptic proteins.