These results were in accordance with previous studies that showed GPR30 activation by G1 rapidly enhanced learning in female CD1 mice61 and ameliorated long‐term recognition memory in an AD mouse model (5XFAD) of male and female mice62 and G15 impaired the acquisition of a spatial learning task in young female rats,26 thus suggesting the important role of GPR30 in mediating the estrogenic effects on spatial learning and memory. Here, GPER1 is linked to Alzheimer disease.