Mutations in MMR genes are observed in 2–3% of CRC patients (Lorans et al., 2018), while approximately 10% of CRC patients exhibit hypermethylation of MLH1 (AlDubayan et al., 2018; Pearlman et al., 2017), contributing to a MMR‐deficient (MMRd) phenotype. Here, MLH1 is linked to colorectal carcinoma.