MLH1 and colorectal carcinoma: Methylation data were not available for the PanCancer Atlas dataset; however, analysis of the TCGA‐COADREAD Provisional dataset (Cerami et al., 2012; Gao et al., 2013) determined that 10.3% of cases (37 out of 358) exhibited hypermethylation of MLH1. The presence of mutations or hypermethylation of promoter regions in one or more DNA repair genes in a CRC cell may contribute to a DNA repair‐defective phenotype that can be used to classify tumor subtypes and to choose an appropriate therapy regimen.