Our findings revealed that BRCA1/ZBRK1 complex could have a function in aspartate metabolism, which was partially dependent on transcriptional regulation of GOT2. Importantly, GOT2 was overexpressed in breast cancer (BC), especially in triple‐negative breast cancer (TNBC), and was significantly correlated with poor survival of patients with these diseases. Here, ZNF350 is linked to breast carcinoma.