In the present study, we demonstrated for the first time that BRCA1 formed a co‐repressor complex with ZBRK1 on the promoter of GOT2 via the ZBRK1 recognition element, and that BRCA1 deficiency promoted aspartate and α‐KG production and accelerated tumor cell growth along with GOT2 upregulation (Fig. 8). This evidence concerns the gene BRCA1 and neoplasm.