Here, we have known that the PD‐1/PD‐L1 axis is a critical pathway leading to T‐cell exhaustion, with the expression of PD‐1 on CD8+ T cells correlating with a severely exhausted T‐cell response.28 However, the understanding of PD‐1/PD‐L1 therapies is still limited in GIST.29, 30 Overall, CD8+ T‐cell exhaustion mechanisms regulated by PD‐1/PD‐L1 in GIST remain largely undefined. The gene discussed is PDCD1; the disease is gastrointestinal stromal tumor.