This observation is explained by the latest study, which reports that cancer cells can send out “drones,” extracellular vesicles mostly in the form of exosomes that carry PD‐L1 on their surface, to battle the immune system from afar.48 That study unveils a mechanism by which tumour cells systemically suppress the immune system, which might also occur in GIST. This evidence concerns the gene CD274 and gastrointestinal stromal tumor.