CD274 and neoplasm: Next, to directly determine the CD8+ T‐cell–intrinsic requirement for PI3K/Akt/mTOR signalling in PD‐L1‐mediated rescue, we examined p‐PI3K, p‐Akt and p‐6s expression in the CD8+ T cells and tumour cells of the four groups by Western blotting (Figure 4A,B).