For instance, F‐box protein FBXW7 functions as a tumor suppressor by promoting proteasomal degradation of c‐Myc, Cyclin E, and Notch, whereas SKP2 functions as an oncogene by promoting degradation of tumor suppressors and activating AKT signaling by abrogating its proteasomal degradation 20. This evidence concerns the gene CCNE1 and neoplasm.