Up‐regulation of RN181 dramatically reduced the percentage of tumour cells that have nuclear staining for cyclin D1 and CDK4 (AGS‐RN181 versus AGS‐RV, p < 0.01) (Figure 3D), while down‐regulation of RN181 significantly increased the percentage of tumour cells showing nuclear accumulation of cyclin D1 and CDK4 (AGS‐KD versus AGS‐NC, p < 0.05) (Figure 3E). Here, CDK4 is linked to neoplasm.