IGHE and infection: An ideal anti-schistosome vaccine would be suitable for use among young children in endemic settings, given their high burden of infection, as well as adults in high-risk occupations; it would achieve 75% reduction in infection intensity (assessed by circulating antigen or egg production); it would require administration of, at most, two doses; it would induce protection lasting at least five to 10 years22; it would not induce IgE; and it would be suitable to co-administer with MDA.