Using a multilocus analysis, we have demonstrated the involvement of a numberof combinations of haplogroup J with the alleles CCL5, PVT1, TNFSF14, and IL4that are not individually associated with MS in the development of MS; thesecombinations are characterized by a greater significance of the associationwith the disease than haplogroup J only. Here, PVT1 is linked to myeloid sarcoma.