Using a multilocus analysis, we have demonstrated the involvement of a numberof combinations of haplogroup J with the alleles CCL5, PVT1, TNFSF14, and IL4that are not individually associated with MS in the development of MS; thesecombinations are characterized by a greater significance of the associationwith the disease than haplogroup J only. This evidence concerns the gene CCL5 and myeloid sarcoma.