CCL5 and myeloid sarcoma: For the combination of haplogroup J with the allelers2107538*A of CCL5, PFLINT equals 0.025 and SF is equal to 4.32[95% CI = 1.2–15.6](Table 3).Thus, it has been demonstrated that the increase in the risk of MS observed incombined carriership of haplogroup J with the CCL5*A allele is associated witha synergistic epistatic interaction between these genetic variants.