Combinations with the alleles of the nuclear genome significantly associatedwith the risk of MS were found only for haplogroup J(Table 2).As a second component, these biallelic combinations included thealleles CCL5 rs2107538*A, PVT1 rs2114358*G,TNFSF14 rs1077667*C and IL4 rs2243250*C,which individually were not significantly associated with MS, and genotypeCLEC16A-SOCS1 rs1640923*A/A, which wassignificantly associated with MS (P = 0.020 and OR = 1.51 [95%CI 1.03–2.20]). Here, IL4 is linked to myeloid sarcoma.