Wesuppose that in tumor stem cells, where the urokinase level is significantlyincreased [142], urokinase istransported mainly to the nucleus, which is facilitated by removal of the firstdomain or the full-length urokinase receptor from the surface of tumor cells byproteases or shedding of the full-length uPAR by PI-PLC[47-52]. The gene discussed is PLAUR; the disease is neoplasm.