TNF and B-cell chronic lymphocytic leukemia: Pathways associated with up-regulated mRNA in PD were centered again on metabolism but the pathways associated with down-regulated mRNAs featured signaling pathways related to TNF, NF-kappa B, Toll-like receptors, and NOD-like receptors, all of which have been studied in the context of CLL pathophysiology (Figure 7) [49–51].