Prognostic models based on Rai stage, immunoglobulin heavy chain variable region mutation status (IGHV), cytogenetic abnormalities, gene mutations and expression of ZAP-70, CD38 and CD49d proteins have been developed and show efficacy in predicting disease outcome in some cases of CLL [1–10]. This evidence concerns the gene ITGA4 and B-cell chronic lymphocytic leukemia.